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. 2018 Jan 23;7:1–14. doi: 10.2147/ITT.S134834

Figure 2.

Figure 2

PS-targeting antibodies interact with β2GP1 and PS to form a high avidity complex.(p)(p)Notes: PS-targeting antibodies 2aG4, 3G4, bavituximab, 1N11, and mch1N11 bind circulating monomeric β2GP1 with low affinity. When sufficient surface exposure is present on a target cell, PS-targeting antibody interacts with two molecules of β2GP1 to form a high avidity (1 nM KD) complex. Domain V of β2GP1 interacts with PS exposed on the target cell. KD, equilibrium dissociation constant.(p)(p)Abbreviations: Ab, antibody; β2GP1, beta 2 glycoprotein-1; PS, phosphatidylserine.