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. 2018 Jan 23;7:1–14. doi: 10.2147/ITT.S134834

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© 2018 Belzile et al. This work is published and licensed by Dove Medical Press Limited

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PET imaging of PS exposed in tumors.(p)(p)Notes: Mice implanted with tumors (PC3-luc) are injected with ¹²⁴I-labeled 1N11 F(ab′)₂ (PGN650) or control F(ab′)₂ probes and imaged by bioluminescence in left panels and PET in middle and right panels. The yellow circle marks the tumor uptake of ¹²⁴I-PGN650. Reproduced from Stafford JH, Hao G, Best AM, Sun X, Thorpe PE. Highly specific PET imaging of prostate tumors in mice with an iodine-124-labeled antibody fragment that targets phosphatidylserine. PLoS One. 2013;8(12):e84864.¹¹²(p)(p)Abbreviations: Ctrl, control; F(ab′)₂, bivalent antigen-binding fragment of an antibody; I-124, iodine 124; luc, luciferase; PET, positron emission tomography; PS, phosphatidylserine.