Table 2.
Subgroup analysis and metaregression of pooled hazard ratios for overall survival in MM patients with high NLR
| Subgroup analysis | No of studies | No of patients | Pooled HR (95% CI) | Metaregression (p-value) | Heterogeneity
|
|
|---|---|---|---|---|---|---|
| I2, % | p-value | |||||
| Region | ||||||
| Western | 4 | 643 | 2.714 (1.992–3.699) | 47.5 | 0.126 | |
| Eastern | 3 | 1,148 | 1.421 (0.924–2.185) | 0.064 | 86.6 | 0.001 |
| Sample size | ||||||
| <200 | 3 | 334 | 2.832 (1.504–5.330) | 0.259 | 60.0 | 0.082 |
| ≥200 | 4 | 1,457 | 1.706 (1.053–2.764) | 89.3 | <0.001 | |
| Cutoff value | ||||||
| =2.0 | 3 | 775 | 1.038 (1.020–1.056) | 0.773 | 99.3 | <0.001 |
| ≠2.0 | 4 | 1,016 | 1.811 (1.445–2.269) | 0.0 | 0.641 | |
| NOS score | ||||||
| ≥8 | 4 | 1,457 | 1.706 (1.053–2.764) | 0.259 | 89.3 | <0.001 |
| <8 | 3 | 334 | 2.832 (1.504–5.332) | 60.0 | 0.082 | |
Abbreviations: HR, hazards ratio; MM, multiple myeloma; NLR, neutrophil–lymphocyte ratio; NOS, Newcastle–Ottawa Quality Assessment Scale.