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. 2018 Jan 29;8:1754. doi: 10.1038/s41598-018-19976-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Patients versus control group after stimulation with PWM, PMA, CD3/28 and LPS. PWM: Pokeweed mitogen, LPS: Lipopolysaccharide, PMA-I: Phorbol myristate acetate and Ionomycin, CD3/28: Cluster of Differentiation 3/28, SS: severe sepsis/septic shock patients. Blood samples were taken subsequently to study enrolment (SS) or at a time of subjective physical well-being (control group), respectively. In boxplots, boxes show the median and interquartile range (IQR), whiskers represent the 10th and 90th percentile. Statistically significant differences (Mann-Whitney Rank Sum Test) are indicated as follows: *p < 0.05, **p < 0.01, ***p < 0.001. Y-axis: logarithmic scale.