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. 2018 Jan 29;8:1793. doi: 10.1038/s41598-018-20067-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fimbrial gene clusters, organization of proteins, and constructs. (A) Five genes encode each fimbria: Mfa1 constitutes the shaft, Mfa2 the anchor, and Mfa3-5 the tip proteins of Mfa1 fimbria (upper) while FimA, FimB and FimC-E constitute shaft, anchor and tip proteins respectively of the FimA fimbria (lower). (B) Mfa1, 3, and 4 start with a signal peptide, followed by a lipidated cysteine. The mature forms are obtained when RgpA/B cleaves the precursors at an exposed arginine (Mfa1, 3 and 4). Mfa2, the anchor protein, is not cleaved. (C) Schematic description of constructs used for crystallographic studies. All constructs used for crystallization screening are depicted as blue bars. The parts of the protein that were observed and modelled in the crystal structures are marked with vertical stripes.