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. 2018 Jan 29;8:1724. doi: 10.1038/s41598-018-20177-8

Figure 2.

Figure 2

The PAX7 10-bp indel affects the binding site of ZNF219. (A) Schematic representation of the putative binding sites of TFs in the presence of Ins-Ins or Del-Del genotypes of the 10-bp indel polymorphism, as predicted by MatInspector Release professional 8.0.4. The sequence of the core binding site of ZNF219 transcription factor was shown, with ci-values of >60 in red and the core sequence in red capitals. Grey ellipses: predicted TFs; white box: TATA box element; dark-gray box: 5′-untranslated region (UTR); light gray box: coding region. (B) ChIP assay of ZNF219 binding to the PAX7 gene promoter with Ins-Ins or Del-Del genotypes. The images were cropped from the same gel, and the full-length gel was shown in Supplementary Fig. S1.