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. 2018 Jan 29;8:1724. doi: 10.1038/s41598-018-20177-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PAX7 promoter activity modulated by the 10-bp indel polymorphism. (A) Luciferase activity in C2C12 cells transfected with recombinant plasmids containing serial promoter fragments (pGL3-pro1, pGL3-pro2, pGL3-pro3, pGL3-pro4, and pGL3-pro5) of the Pax7 promoter. The backbone vector pGL3-Basic was used as a negative control. P_{pGL3-pro2 vs. pGL3-pro1} = 0.0118, P_{pGL3-pro2 vs. pGL3-pro3} = 0.0042, P_{pGL3-pro2 vs. pGL3-pro4} = 0.0495, P_{pGL3-pro2 vs. pGL3-pro5} = 0.0241. (B) Luciferase activity in C2C12 cells transfected with recombinant plasmids containing the Ins-Ins or Del-Del genotype. pcDNA3.1-ZNF219 was transiently co-transfected into C2C12 cells together with the reporter vectors. Each experiment was repeated at least three times. The data were mean ± standard error (S.E.) of the normalized luciferase activity. *P < 0.05 represents a significant difference.