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. 2018 Jan 29;8:1783. doi: 10.1038/s41598-018-19961-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dependence of Aβ42 amyloid aggregation on incubation time and Aβ42 concentration. Examples of FCS measurements of samples with labelled Aβ42, Aβ*, mixed with different concentrations of unlabelled Aβ42, Aβ°: (a) experimental and fitted correlation curves at different incubation times for a fixed total amyloid concentration in solution of 0.36 μM; (b) experimental and fitted FCS curves for different Aβ42 concentrations at the same short incubation time of 10–15 min; (c) diffusion times of the aggregates (τ_D2) determined from the FCS curves of panel a against incubation time; (d) mean diffusion times of the aggregates (τ_D2) obtained from the FCS curves measured at different incubation times for each sample against total Aβ42 concentration; (e) contribution of the aggregates (1-R) to the diffusion term for the FCS curves of panel a against incubation time; (f) mean contribution of the aggregates (1-R) obtained from the FCS curves measured at different incubation times for each sample against total Aβ42 concentration. The error bars in panels d and f indicate the standard deviation of the values measured for each sample at different incubation times. The Aβ42 concentration refers to the experimentally determined real concentrations in solution.