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. 2018 Jan 29;8:1719. doi: 10.1038/s41598-017-19135-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Real-time NMR spectra demonstrating spontaneous, sequential interconversions among different lid domain conformations in the transition pathway between two extreme conformations: open and closed (T = 310 K, pH 7.4). Variable temperature NMR experiments demonstrating (b) temperature effect on the rate of exchange between open conformations of sol-hMGL and (c) effect of temperature on the distribution of open-closed conformers for the H272A mutant (pH 7.4).