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. 2018 Jan 23;13:493–504. doi: 10.2147/IJN.S152474

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© 2018 Ghassami et al. This work is published and licensed by Dove Medical Press Limited

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Viability percent after 24 hours incubation of (A) SKOV-3 cells treated with DTX-NPs, Apt-DTX-NPs, and free drug with different concentrations in the range of 100–1,000 ng/mL, and (B) MDA-MB-468 cells treated with DTX-NPs, Apt-DTX-NPs, and free drug with different concentrations in the range of 10–100 ng/mL, and compared to control samples including blank NPs (NPs which were not loaded with DTX) and DMSO (in the maximum concentration used in treatment groups).

Note: Significant differences are marked as *p<0.05.

Abbreviations: DTX, docetaxel; DTX-NPs, non-targeted nanoparticles loaded with docetaxel; Apt-DTX-NPs, aptamer-conjugated nanoparticles loaded with docetaxel; Blank NPs, nanoparticles not loaded with DTX; DMSO, dimethyl sulfoxide.