Table 1.
Pharmacokinetic parameters of Taxotere® and Apt-DTX-NPs (results are presented as mean ± SD; n=3)
| Formulations | AUC0–∞ (µg⋅h/mL) | CL (L/kg/h) | MRT (hours) | Vd (L/kg) | T1/2β (hours) | T1/2α (hours) |
|---|---|---|---|---|---|---|
| Taxotere® | 4.51±0.39* | 1.11±0.10* | 3.95±0.07* | 4.38±0.30 | 2.70±0.05* | 0.63±0.03 |
| Apt-DTX-NPs | 6.97±0.84 | 0.72±0.09 | 6.19±0.17 | 4.44±0.41 | 4.30±0.12 | 0.67±0.03 |
| DTX-NPs | 6.34±1.02 | 0.78±0.12 | 5.91±0.42 | 4.66±1.08 | 4.10±0.29 | 0.64±0.03 |
Note:
*
p<0.05.
Abbreviations: Apt-DTX-NPs, aptamer-conjugated nanoparticles loaded with docetaxel; AUC, area under the curve; CL, clearance; DTX-NPs, non-targeted nanoparticles loaded with docetaxel; MRT, mean residence time; Vd, volume of distribution; T1/2β, elimination half-life; T1/2α, biodistribution half-life.