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. 2018 Jan 29;8:1759. doi: 10.1038/s41598-018-19816-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of CMS and cocaine on locus coeruleus-hippocampal tract activity. Mice were exposed to CMS or no stress for 4 weeks, then treated with cocaine (15 mg/kg) or saline for 1 week in the CPP protocol. Letters above bars: one-way ANOVA with Bonferroni means separation test comparing: treatments within mouse strains [abc] or treatments across mouse strain [*]. (A) Dopamine receptor 1 (DRD1: WT: [F(3,16) = 4.303, p = 0.0209]; Sub: [F(3,16) = 17.43, p < 0.0001]; CMS: [F(2,12) = 7.49, p = 0.0077; CMS + Drug: [F(2,12) = 8.431, p = 0.0052]). (B) Dopamine receptor 2 (DRD2: Sub: [F(3,16) = 15.89, p < 0.0001]; Drug: [F(2,12) = 18.02, p = 0.0002; CMS + Drug: [F(2,12) = 6.695, p = 0.0111]).