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. 2018 Jan 29;8:1808. doi: 10.1038/s41598-018-20052-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Perturbed hematopoiesis is retained in Asah1^P361R/P361R;MCP-1^−/− mice. (A) FACS plots showing B-cell lineage staining in BM from 9-week-old mice of all genotypes. (B) Histology staining of BM with H&E along with anti-B220, anti-CD-3, and anti-Mac-2 antibodies. (C) The absolute number of Pro-B, Pre-B, immature B, transitional B, and mature B cells in mice bone marrow (BM). (D) The absolute number of CD11b⁺ and Gr-1⁺ cells in mouse BM, thymus, and spleens. (E) The absolute number of CD4⁺ CD8⁻, CD4⁻ CD8⁺, and CD4⁺ CD8⁺ cells in mouse thymus. 9- and 12-week-old mice were used for the histopathology analyses. Original magnification of BM micrographs at 10x where scale bar represents 300 µm. Spleen and thymus micrographs are at 4x magnification and the scale bar represents 100 µm. n = 3–4 mice at 9 weeks of age were used for FACS analysis and cell counts. ns (not significant), *p < 0.05 **p < 0.01, ***p < 0.001.