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. 2018 Jan 29;8:1808. doi: 10.1038/s41598-018-20052-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Delayed signs of liver injury and fibrosis in Asah1^P361R/P361R;MCP-1^−/− mice. Light micrographs of liver sections stained for hematoxylin and eosin (H&E), Masson’s trichrome, and immunohistochemistry (IHC) for Mac-2 in 8–9-week-old Asah1^+/+;MCP-1^+/+ mice (A), 8–9-week-old Asah1^+/+;MCP-1^−/− mice (B), 8–9-week-old Asah1^P361R/P361R;MCP-1^+/+ mice (C), 8–9-week-old Asah1^P361R/P361R;MCP-1^−/− mice (D), and 11–12-week-old Asah1^P361R/P361R;MCP-1^−/− mice (E). The original magnification of the top panel is 20x where the scale bar represents 100 µm and the original magnification of the bottom panel is 40x where the scale bar represents 50 µm. Liver function metabolites and enzymes were analyzed in serum from 8–9-week-old mice for each genotype, and samples from 11–12-week-old Asah1^P361R/P361R;MCP-1^−/− mice. Analytes from the biochemistry panel include; Albumin (F), alkaline phosphatase (ALP) (G), alanine aminotransferase (ALT) (H), n = 7–9 mice per group. ELISA for aspartate aminotransferase (AST) (I). All comparisons were made between 8–9-week-old Asah1^P361R/P361R;MCP-1^+/+, 8–9-week-old Asah1^P361R/P361R;MCP-1^−/− and 11–12-week-old Asah1^P361R/P361R;MCP-1^−/− mice. n = 8 mice per group. ns (not significant), *p < 0.05, **p < 0.01,***p < 0.001.