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. 2018 Jan 29;8:1808. doi: 10.1038/s41598-018-20052-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sphingolipid accumulation and abundance changes are organ specific in the Asah1^P361R/P361R;MCP-1^−/− mice. Percentage distribution of all total sphingolipids measured in liver, lung, and brain tissue lysates (A–C). Ceramide (Cer) species in liver, lung, and brain (D–F). Relative abundance of Cer species in liver, lung, and brain (G–I). Sphingomyelin (SM) species in liver, lung, and brain (J–L) and relative abundance of SM species in liver, lung, and brain (M–O). n = 4–6 per genotype. All comparisons were made between samples from 8–9-week-old Asah1^P361R/P361R;MCP-1^+/+, 8–9-week-old Asah1^P361R/P361R;MCP-1^−/− and 11–12-week-old Asah1^P361R/P361R;MCP-1^−/− mice. ns (not significant), *Represents post-hoc test compared to Asah1^+/+;MCP-1^+/+ *p < 0.05, **p < 0.01,***p < 0.001. ^#Represents post-hoc test compared to Asah1^P361R/P361R;MCP-1^{+/+ #}p < 0.05.