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. 2018 Jan 29;8:1722. doi: 10.1038/s41598-018-20192-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of active compounds 1 and 1i at the indicated concentrations on the cell cycle of PC-3 cells. The cultured cells were treated with these compounds at the indicated concentrations for 48 h, then harvested, and analyzed by flow cytometry. VP-16 and Parthenolide (P) treatments were set as positive groups. Each experiment was performed in triplicate.