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Cytotoxic activities (IC50) of C13-methylene modified derivatives.
| No. | IC50a (μM) | |
|---|---|---|
| PC-3 | HepG2 | |
| 1j | >40 | >40 |
| 1k | >40 | >40 |
| 1l | >40 | >40 |
| 1m | >40 | >40 |
| 1n | >40 | >40 |
| 1o | >40 | >40 |
| 1p | >40 | >40 |
| 1q | >40 | >40 |
| 1r | >50 | >50 |
| 1s | >50 | >50 |
aCells were treated with compounds for 72 h. All data (mean ± SD) are the average of three or four independent experiments in triplicate.
