. 2018 Jan 29;8:1789. doi: 10.1038/s41598-018-19957-z

Table 2.

Age- and sex-related Abs prevalence in RA patients and HCs.

Gender	Age (y)	N	Subjects	BOLF1	P	IRF5	P	MAP_4027	P	IL-2 _56–70	P	IL-2 _6–20KK	P	Herv-K_19–37	P
Females	≤49	16	RA	12 (75%)	<0,0001	15 (93,75%)	<0,0001	5 (31,25%)	0,0063	5 (31,25%)	0,088	8 (50%)	<0,0001	5 (31,25%)	0,38
	≤49	65	HCs	8 (12,30%)	<0,0001	6 (9,2%)	<0,0001	5 (7,6%)	0,0063	9 (13,8%)	0,088	6 (9,2%)	<0,0001	9 (13,8%)	0,38
	50–59	41	RA	21 (51,21%)	<0,0001	23 (56,09%)	<0,0001	8 (19,51%)	0,51	10 (24,39%)	0,045	20 (48,78%)	<0,0001	9 (21,95%)	0,13
	50–59	19	HCs	2 (10,52%)	<0,0001	1 (5,2%)	<0,0001	3 (15,78%)	0,51	1 (5,2%)	0,045	1 (5,2%)	<0,0001	1 (5,2%)	0,13
	≥60	49	RA	17 (34,69%)	0,17	25 (51,02%)	0,024	11 (22,44%)	0,92	12 (22,44%)	0,61	17 (34,69%)	0,081	15 (30,61%)	0,17
	≥60	6	HCs	1 (16,66%)	0,17	1 (16,66%)	0,024	0	0,92	1 (16,66%)	0,61	1 (16,66%)	0,081	0	0,17
Males	≤49	6	RA	4 (66,66%)	0,0046	6 (100%)	0,0001	3 (50%)	0,094	3 (50%)	0,302	4 (66,66%)	0,0449	2 (33,33%)	0,34
	≤49	15	HCs	2 (13,33%)	0,0046	1 (6,6%)	0,0001	4 (13,3%)	0,094	1 (6,6%)	0,302	2 (13,33%)	0,0449	1 (6,6%)	0,34
	50–59	11	RA	2 (18,18%)	0,0023	3 (27,27%)	0,535	1 (9%)	0,43	2 (9%)	0,015	1 (18,18%)	0,0006	2 (18,18%)	0,198
	50–59	23	HCs	0	0,0023	3 (13,04%)	0,535	1 (4,3%)	0,43	1 (4,3%)	0,015	0	0,0006	1 (4,3%)	0,198
	≥60	17	RA	5 (29,41%)	0,0035	7 (41,17%)	0,104	3 (17,64%)	0,0246	1 (5,8%)	0,0211	4 (23,52%)	0,0005	1 (5,8%)	0,652
	≥60	9	HCs	0	0,0035	1 (11,1%)	0,104	0	0,0246	0	0,0211	0	0,0005	1 (11,1%)	0,652

The numbers of individuals responsive to single antigens are provided with relative percentages. Statistically significant values are highlighted in bold.