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. 2018 Jan 28;11(2):250–258. doi: 10.1016/j.tranon.2018.01.001

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

The antitumor effect of PD-1 Ab, sorafenib and DC-TEX in HCC mice. The established HCC orthotopic mice were administered PD-1 Ab, sorafenib and DC-TEX alone or in combination. A. We observed no significant differences in tumor sizes by MRI in the different groups before treatment (n = 6 mice/group, P > .05). B Measurement of tumor volume after treatment for 7 days. The triple combination treatment exhibited a significantly superior effect (n = 6 mice/group, **P < .01). C. Serum AFP levels using ELISA significantly decreased in the triple combination group (n = 6 mice/group, **P < .01). D. The triple combination treatment group exhibited a significantly prolonged survival time (n = 10 mice/group, **P < .01).