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. 2018 Jan 16;7(1):13. doi: 10.3390/antiox7010013

Figure 3.

Figure 3

Drivers of fission-induced mitochondrial ROS production. Mitochondrial network fragmentation can occur at both extremes of ∆Ψm. Whereas low ∆Ψm values result from insults causing mitochondrial dysfunction (top), high ∆Ψm values can be achieved by metabolic stimulation such as with high glucose (bottom). Both stimuli result in fragmented organelles and subsequent generation of superoxide by ETC.