Table 2.

Ingenuity pathway analysis of functional networks affected by replicative senescence.

Network	Members	Molecules	Associated Groups or Molecules
Free radical scavenging, molecular transport, cancer	20	ACTA1, ACTG1, ANXA1, ANXA5, CASP8AP2, CTSD, FDXR, HSPB1, LMNA, PHB2, PHB, PRDX2, PRDX6, PSMD14, SMS, SOD1, SOD2, STRAP, TRAP1, VIM	14-3-3, 26S Proteasome, caspase, CD3, Cytochrome c, estrogen receptor, F actin, glutathione peroxidase, hemoglobin, Insulin, Lh, NFkB (complex), Rb, Ubiquitin
Developmental disorder, neurological and inherited diseases	13	BLVRA, EIF4A1, ETFA, GARS, GNB2L1, IMMT, PKM2, RAB11A, RCN1, TALDO1, TMEM132D, UCHL1, VSP13D	AkT, Ap1, CENPI, ERK1/2, FAM189B, FRY, FSH, Histone h3, Jnk, LEMD2, Mapk, NUDT6, P38 MAPK, PDGFB, PI3K (complex), Pkc(s), PTCD2, SLC9A6, SPRED3, UBC, USP35, USP40
Cancer, neurological disease and cell signaling	1	CEP104	NR2F6