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Central pathway for fatty acid and cholesterol synthesis (ACC: Acetyl-CoA carboxylase; ACLY: ATP-citrate lyase; AMPK: AMP-activated protein kinase; ER: endoplasmic reticulum; FA: fatty acid; FASN: fatty acid synthase; HMG: 3-hydroxy-3-methylglutaryl-coenzyme A; LKB1: liver kinase B1; LDLR: low-density lipoprotein receptor; SCD: ∆9-stearoyl-CoA desaturase; SREBP: sterol regulatory element-binding protein; TCA cycle: tricarboxylic acid cycle).
