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Numerical and structural CIN arise during mitotic chromosome segregation errors. Dysfunctional chromosome duplication or segregation during mitosis can conduce to whole chromosome gains and losses (numerical CIN) and/or alterations in the structure of chromosomes (structural CIN) including translocations, deletions, and derivative chromosome, among other. Both numerical and structural alterations predispose chromosomes to subsequent chromosomal alterations, thereby increasing CIN.
