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. 2018 Feb 5;215(2):415–422. doi: 10.1084/jem.20170536

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© 2018 Herro et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 3. — HVEM regulates proliferation and periostin expression in keratinocytes. (a and b) Human epidermal keratinocytes were cultured with PBS or rLIGHT for 72 h with or without siRNA knockdown of HVEM. (a) Proliferation (tritiated thymidine incorporation). Data are from three to five individual replicate cultures. (b) Periostin expression by IF stain (red) and mRNA expression of TSLP and periostin. Scr, scrambled siRNA. Data are representative of (or means ± SEM from) three replicate cultures. (c) WT mice were injected s.c. with rLIGHT for 2 d. Periostin IF stain on skin tissue or mRNA in biopsy specimens by quantitative PCR on day 3 (means ± SEM). (d) K14-cre HVEM^+/+ or K14-cre HVEM^fl/fl mice were injected s.c. with rLIGHT for 2 d. Periostin IF stain on skin tissue on day 3. All results are representative of three experiments. Bars, 200 µm. *, P < 0.05; **, P < 0.1. All statistical data were generated using the Mann–Whitney test.