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. 2018 Feb 5;215(2):521–535. doi: 10.1084/jem.20170686

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© 2018 Sun et al.

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Figure 4. — IFN-γ signaling in macrophages is essential for impairing neurological recovery from SCI. (A–C) After SCI, behavioral tests were assessed in WT, IFN-γ^−/−, and IFN-γR^−/− mice. (A) Statistical analysis comparing IFN-γ^−/− and WT mice (*, **) or IFN-γR^−/− and WT (#, ##). (B and C) Regularity index and hind max contact area with CatWalk test (C). (D–F) Irradiated WT mice were reconstituted with bone marrow from WT or IFN-γR^−/− mice and tested for recovery. (G) BMSs were measured in irradiated WT mice injected with peritoneal macrophages prepared from WT or IFN-γR^−/− mice or PBS alone. Error bars represent mean ± SEM. (A, D, and G) Two-way repeated measures ANOVA with Bonferroni’s post-hoc correction. (B, C, E, and F) One-way ANOVA with Tukey’s multiple comparisons test. * or #, P < 0.05; ** or ##, P < 0.01; ***, P < 0.001. n = 8. M_Ø, macrophages.