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. 2018 Feb 5;215(2):627–644. doi: 10.1084/jem.20170690

Figure 2.

Figure 2.

Functional impact of obesity on HSCs. (A) Experimental scheme for serial transplantation assay. (B and C) Hematopoietic reconstitution in primary and secondary recipients. The left graph indicates PB chimerism over time. The middle graph shows myeloid and lymphoid PB chimerism 20 wk after transplantation. The right graph shows the percentage of donor-derived total BM cells, SLAM HSCs, MPPs, and myeloid progenitors (MPs) 20 wk after transplantation. Results are expressed as means ± SEM. n = 8 and 4. Student’s t test; *, P ≤ 0.05; **, P ≤ 0.01. Four and two independent experiments, respectively.