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. 2018 Feb 5;215(2):383–396. doi: 10.1084/jem.20171965

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© 2018 Shapiro et al.

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Figure 1. — Regulation of BA synthesis by repression of Cyp7a1 is mediated by FXR signaling. BA-FXR signaling in the liver activates SHP, which negatively controls Cyp7A1 expression. Intestinal BA-FXR signaling induces FGF15/19 expression. Release of intestinal FGF15/19 followed by binding of FGF15/19 to hepatic FGFR4/βKlotho leads to repression of hepatic Cyp7A1 and Cyp8B1.