Table 3.
In vitro antibacterial, antifungal and cytotoxic activity of compounds 9, 14 and 17 in comparison with positive controls.
| Test organism | 9a | 14a | 17a | Reference |
| Fungi | ||||
| Candida albicans DSM 1665 | – | – | 16.6 | 33.3b |
| Mucor hiemalis DSM 2656 | 33.3 | – | 16.6 | 5.25–16.6b |
| Pichia anomala DSM 70255 | – | – | 33.3 | 33.3b |
| Rhodotorula glutinis DSM 10134 | – | – | 16.6 | 0.52–16.7b |
| Schizosaccharomyces pombe DSM 70572 | – | – | 16.6 | 42.0–67.0b |
| Bacteria | ||||
| Bacillus subtilis DSM 10 | – | – | 67.0 | 6.7–8.3c |
| Chromobacterium violaceum DSM 30191 | 67.0 | – | – | 0.83–8.3c |
| Escherichia coli DSM 1116 | – | – | – | 0.83c |
| Micrococcus luteus DSM 20030 | – | – | – | 0.42c |
| Mycobacterium sp. DSM 43270 | – | – | – | 2.1c |
| Pseudomonas aeruginosa DSM 50071 | – | – | – | 16.6–21.0d |
| Staphylococcus aureus DSM 346 | – | – | 67.0 | 0.1–0.21c |
| Eukaryotic cell line | ||||
| Murine cell line L929 | >10 | 6 | >10 | 1 nme |
aFor compound testings against bacteria and fungi minimum inhibitory concentrations (MIC) in μg mL−1 are given, for cytotoxicity testings against the murine cell line the IC50 is given in μg mL−1. Reference compounds: bnystatin, coxytetracyclin hydrochloride, dgentamycin, eepothilon B.