Table 2.
Nucleophilic substitution reactions of 7-[2H1]-(R)-benzyl fluoride ((R)-1).
| Entry | Reaction | ee (%) |
| 1 | ![]() |
94 |
| 2 | ![]() |
90 |
| 3 | ![]() |
nda |
| 4 | ![]() |
93 |
| 5 | ![]() |
91 |
| 6 | ![]() |
87 |
| 7 | ![]() |
nda |
| 8 | ![]() |
89 |
aee could not be determined as a result of poor 2H{1H} NMR resolution.
Nucleophilic substitution reactions of 7-[2H1]-(R)-benzyl fluoride ((R)-1).
| Entry | Reaction | ee (%) |
| 1 | ![]() |
94 |
| 2 | ![]() |
90 |
| 3 | ![]() |
nda |
| 4 | ![]() |
93 |
| 5 | ![]() |
91 |
| 6 | ![]() |
87 |
| 7 | ![]() |
nda |
| 8 | ![]() |
89 |
aee could not be determined as a result of poor 2H{1H} NMR resolution.