Table 6.
Mixed model analyses of decrements in cognitive functioning in youth with ASD and mood disorders with and without comorbid ADHD (controlling for age, sex, and medication use)
| Analysis 1: ASD | |||
|---|---|---|---|
| Effectsa | β (SD) | p-value | Wald’s test |
| Main effect cognition | χ2 (4)=28.58, p<.001 | ||
|
| |||
| GAI (reference category) | - | - | |
| RT variability | −.35 (.17) | .04* | |
| Working Memory | −.74 (.16) | <.001 | |
| Inhibition | −.57 (.17) | .001 | |
| Shifting | −.70 (.17) | <.001 | |
|
| |||
| Main effect diagnosis | χ2 (1)=0.21, p=.65 | ||
|
| |||
| ASD (reference category) | - | - | |
| ASD + ADHD | .09 (.20) | .65 | |
|
| |||
| Analysis 2: Mood disorder | |||
| Effectsa | β (SD) | p-value | Wald’s test |
|
| |||
| Main effect -cognition | χ2 (4)=48.59, p<.001 | ||
|
| |||
| GAI (reference category) | - | - | |
| RT variability | −.69 (.13) | <.001 | |
| Working Memory | −.57 (.12) | <.001 | |
| Inhibition | −.72 (.13) | <.001 | |
| Shifting | −.70 (.12) | <.001 | |
|
| |||
| Main effect -diagnosis | χ2 (1)=5.41, p=.02 | ||
|
| |||
| Mood disorder (reference category) | - | - | |
| Mood disorder + ADHD | −.33 (.14) | .02 | |
*
Asterisk=non-significant; critical value after Bonferroni correction for multiple cognitive tests is 0.0125.
a
Interaction between diagnosis and cognition is not shown because of a lack of statistical significance.