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. 2018 Jan 25;6(2):e13565. doi: 10.14814/phy2.13565

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© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Individual values of mean pulmonary artery pressure (mPAP); (A), mean pulmonary wedge pressure (mPCWP); (B), and transpulmonary gradient (TPG); (C) as a function of cardiac output (Q; direct Fick) in those subjects with catheters (N = 4 younger and 5 older) during incremental exercise in younger (black) and older (gray) healthy adults presildenafil (circles and solid line) and postsildenafil (triangles and dotted line). The data were fit using a linear mixed effects model. mPAP is significantly greater in older adults (A; P = 0.029). mPAP, mPCWP, and TPG are significantly reduced following sildenafil administration (all P < 0.001).