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Statins reduce leptin expression in white adipocytes. Treatment with increasing concentrations of simvastatin lowered leptin mRNA (A) and leptin secretion (B). Treatment with increasing concentrations of atorvastatin lowered leptin mRNA (C) and leptin secretion (D). Data are presented as mean ± SEM (n = 3 independent experiments). *P < 0.05 compared with control as determined by Wilcoxon rank‐sum test. Appropriate vehicle controls were used for each experiment.
