Table 2.
Summary of neuropsychological evaluation.
| C + (n = 17) | C– (n = 15) | HC (n = 18) | p-Value | |
|---|---|---|---|---|
| Cognitive impairmentc | 5 (29%) | 3 (20%) | 1 (6%) | 0.18 |
| Mattis dementia rating scale-2a | 144 (133–144) | 144 (140–144) | 144 (139–144) | 0.91 |
| BDI (≥ 13)c | 5 (29) | 4 (27) | 2 (11) | 0.30 |
| Estimated verbal IQ | ||||
| WAIS-III vocabulary sub-test | 0 ± 1.03⁎ | 0.21 ± 0.73 | 1.05 ± 1.13 | 0.01 |
| Language | ||||
| Brief Spanish adaptation of the Boston naming test | 0.33 ± 0.86 | 0.25 ± 0.59 | 0.56 ± 0.68 | 0.59 |
| Verbal fluency | ||||
| Semantic fluency | 0.43 ± 0.70 | 0.28 ± 0.65 | 0.30 ± 0.76 | 0.67 |
| Phonemic fluency | − 0.33 ± 1.23 | − 0.23 ± 1.12 | 0.5 ± 0.72 | 0.05 |
| Processing speed/executive functions | ||||
| Trail Making test A (TMT-A) | − 0.45 ± 0.87 | − 0.08 ± 0.72 | 0.31 ± 0.97 | 0.06 |
| Trail Making test B (TMT-B) | − 0.83 ± 0.82⁎ | − 0.41 ± 0.99 | − 0.02 ± 0.75 | 0.04 |
| TMT-B minus TMT-A (in seconds)a | 144 ± 96⁎ | 112 ± 118 | 66 ± 45 | 0.02 |
| Attention/working memory | ||||
| WAIS-III digits sub-test | 0.15 ± 1.12 | 0.28 ± 0.57 | 0.65 ± 0.80 | 0.20 |
| Visuospatial abilities | ||||
| ROCF first copy | 0.60 ± 1.05⁎ | 1.23 ± 1.24 | 1.68 ± 1.03 | 0.03 |
| Visual memory | ||||
| ROCF delayed | 0.43 ± 0.80 | 1 ± 0.97 | 0.78 ± 0.73 | 0.26 |
| Verbal memorya | ||||
| AVLT immediate recall (A1) | 4.06 ± 2.01 | 3.43 ± 1.28⁎⁎ | 5.06 ± 1.62 | 0.03 |
| AVLT immediate recall (B) | 4.50 ± 0.85 | 4.86 ± 1.77 | 5 ± 1.37 | 0.60 |
| AVLT short-delay recall(A6) | 5.86 ± 1.61 | 6.71 ± 3.45 | 7.72 ± 3.23 | 0.23 |
| AVLT long-delay recall(A7) | 5.38 ± 2.55 | 6.21 ± 3.11 | 7.39 ± 3.52 | 0.29 |
All results are z-scores mean ± SD except for araw score, bmedian (range), cn (%).
C +: chemotherapy-treated small-cell lung cancer group; C −: non-chemotherapy treated non-small cell lung cancer group; HC: healthy control group; BDI: Beck Depression Inventory test, IQ: intelligence quotient, WAIS-III: Wechsler Adult Intelligence Scale-III, ROCF: Rey-Osterrieth Complex Figure, AVLT: Auditory Verbal Learning Test.
Statistically significant results are marked in bold.
⁎
Significant differences were between C + and HC.
⁎⁎
Significant differences were between C– and HC.