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. Author manuscript; available in PMC: 2018 Jan 30.
Published in final edited form as: Genes Immun. 2014 Jun 5;15(6):370–377. doi: 10.1038/gene.2014.28

Table 4.

Test of heterozygote protection at rs2075609 and/or rs4147780

Guinea-Bissau The Gambia Italy
(Capparelli et al, 2009)
Tested Haplotype Model OR (95% CI)2 P3 OR (95% CI)2 P3 OR (95% CI)2 P3
Heterozygous at only rs2075609 1.16 (0.76–1.77) 0.492 1.17 (0.73–1.90) 0.499 0.38 (0.22–0.66) 0.001
Heterozygous at only rs4147780 0.86 (0.49–1.49) 0.580 1.11 (0.64–1.91) 0.712 0.35 (0.31–0.54) 2×10−6
Heterozygous at both loci 0.80 (0.54–1.18) 0.264 1.16 (0.73–1.83) 0.539 0.26 (0.16–0.41) 7×10−9
All heterozygous1 0.93 (0.67–1.28) 0.641 1.15 (0.79–1.67) 0.457 0.32 (0.23–0.45) 3.3×10−11

Double homozygotes (individuals with haplotypes: 13/13, 23/23, 14/14, 24/24) were used as the reference group for all models tested above.

1

Individuals who are heterozygous at either rs2075609 or rs4147780 or both

2

OR: Odds ratio, 95% CI: 95% Confidence Interval

3

P: p-value for specified logistic regression model