. Author manuscript; available in PMC: 2018 Jan 30.

Published in final edited form as: Genes Immun. 2014 Jun 5;15(6):370–377. doi: 10.1038/gene.2014.28

Table 5.

a. Top Visualization of Statistical Epistasis Networks (ViSEN) results for EREG/TCIRG1 SNPs and demographic variables for TB susceptibility in Guinea-Bissau
Predictor 1	Predictor 2	IG¹	IG P-value²
AGEQRT³	SEX	5.02%	<0.001
AGEQRT	ETHGRP⁴	3.50%	0.010
ETHGRP	rs4147779	2.27%	0.014
ETHGRP	rs906713	1.93%	0.015
ETHGRP	rs1563826	1.53%	0.044
AGEQRT	rs7675690	1.46%	0.006
AGEQRT	rs12641042	1.17%	0.012
rs12641042	rs906713	1.06%	0.008

b. Top Visualization of Statistical Epistasis Networks (ViSEN) results for EREG/TCIRG1 SNPs and demographic variables for TB susceptibility in The Gambia
Predictor 1	Predictor 2	IG¹	IG P-value²
ETHGRP	rs7675690	3.41%	0.010
ETHGRP	rs1563826	2.60%	0.032
ETHGRP	rs11228127	2.19%	0.038
ETHGRP	rs4147780	2.17%	0.043
ETHGRP	rs4147779	2.06%	0.049
rs7675690	rs10896289	2.03%	<0.001
AGEQRT	rs10896289	1.85%	0.011
rs1563826	rs10896289	1.82%	0.005
rs7675690	rs1122812	1.54%	0.003
rs4147779	rs906713	1.18%	0.006
rs1563826	rs906713	1.07%	0.022

Note: Pairwise interactions presented above are comprised of all statistically significant pairwise interactions with IG > 1.00%.

Information Gain (IG) = Percentage of information gained about TB Status from considering Predictor 1 and Predictor 2 together after controlling for main effects from both variables

Information Gain p-value; p-value is based on 1000 permutations

AGEQRT = Age (quartile)

⁴

ETHGRP = Ethnicity