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. Author manuscript; available in PMC: 2018 Jan 30.
Published in final edited form as: Virology. 2013 May 29;443(1):11–19. doi: 10.1016/j.virol.2013.04.033

Figure 6.

Figure 6

Role of CDKs in regulating promoter activity. (a) Keratinocytes maintaining episomal HPV16 were treated or untreated with a CDK4/6 inhibitor and total RNAs were subjected to Northern analysis using the HPV16 genome as a probe. (b) HPV16-containing keratinocytes were cotransfected with luciferase reporters for the late promoter and expression vectors for E7, DN-CDK1, or DN-CDK2. Following culture in monolayer or MC for 24 hours, luciferase activities were measured and normalized as described in Figure 1. V, pcDNA empty vector; pGL, empty luciferase reporter vector. Values represent the means of 5-9 independent experiments and bars represent ± one standard error of the mean.