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. 2018 Jan 30;8:1893. doi: 10.1038/s41598-018-20084-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Two WMH with a different eccentricity value. This figure represents two WMH that have a different eccentricity value. The shown FLAIR images have a voxel size of 0.96 × 0.96 × 3.00 mm³. The left panels show a punctuate deep WMH with a low eccentricity of 1.0 (close to spherical), which is seen in only one slice. The right panels show a punctuate deep WMH with a high eccentricity of 4.2 (strongly ellipsoidal), which is caused by the lesion extending in multiple slices. As can be appreciated, this difference in WMH shape can also be perceived visually.