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. 2018 Jan 30;8:1904. doi: 10.1038/s41598-018-20314-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ELVd (sequence variant AJ536613) folded in the predicted secondary structure of minimum free energy. The domain and self-cleavage site of the hammerhead ribozyme are indicated on yellow background and by a red arrowhead, respectively. The internucleotide position U245-U246 where the RNAs of interest were grafted is indicated by a blue arrow.