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. 2018 Jan 30;8:1838. doi: 10.1038/s41598-018-20216-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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P2X₄ is expressed in bladder wall but not in BSM. Cryosections of mouse (wild type and P2X₄−/−) bladders were labelled with antibodies to P2X₄ (green), P2X₁ (green), ENTPD2 (red), and Topro-3 to label nuclei (blue). Entpd2 (middle panels) labels interstitial cells among muscle bundles. Colour merged panels are shown on the right and merged signals are seen as yellow. White arrowheads (top left) indicate P2X₄ labelling of unknown cellular structures. White arrows (middle left) indicate non-specific labelling by anti-P2X₄ antibody in P2X₄−/− mice. P2X₁ receptors are abundantly expressed in BSM and that signal is clearly differentiated from interstitial cell staining (red). White scale bars = 10 µm.