Table 1.
rs2045145: Association with female profile PC2 European-like extreme
| Discovery | aa | Aa | AA | P value | OR |
| Extremes | 6 | 7 | 63 | 8.65 × 10−5 | 9.70 |
| Controls* | 27 | 564 | 2,492 | ||
| Replication | |||||
| Extremes | 3 | 9 | 70 | 2.85 × 10−3 | 4.67 |
| Controls | 31 | 727 | 3,089 | FDR = 0.026 | |
| Combined | |||||
| Extremes | 9 | 16 | 133 | 1.11 × 10−6 | 7.44 |
| Controls | 31 | 727 | 3,089 |
The 3 × 2 tables for PoBI discovery, TwinsUK replication, and the combined data. Minor allele (a) frequency 0.103. P values and OR are for the minor allele (aa) recessive homozygote; FDR by Benjamini and Hochberg procedure (37). Male imaged individuals were excluded from the discovery analysis. The number of controls for discovery is the total number of genotyped individuals, 3,161, minus the number of extremes, 76, minus 2 missing genotypes. The number of controls for replication and combined is the number for discovery (3,083) plus the number of genotyped and phenotyped twins (∼865) minus the number of extreme twins (82) minus 18 twins not typed for this SNP.
Two genotypes missing for technical reasons.