Table 2.
rs11642644 (MBTPS1) associations with profile PC7 upper extreme in females
| Discovery | aa | Aa | AA | P value | OR |
| Extremes | 6 | 15 | 56 | 7.38 × 10−5 | 9.57 |
| Controls | 27 | 578 | 2,479 | ||
| Replication | |||||
| Extremes | 3 | 13 | 69 | 2.7 × 10−3 | 4.48 |
| Controls | 31 | 688 | 3,110 | FDR = 0.026 | |
| Combined | |||||
| Extremes | 9 | 28 | 125 | 1.79 × 10−6 | 7.21 |
| Controls | 31 | 688 | 3,110 |
Minor allele (a) frequency 0.097. P values and OR are for the minor allele (aa) recessive homozygote; FDR Benjamini and Hochberg procedure (37). Male imaged individuals were excluded from the discovery analysis. The number of controls for Discovery is the total number of genotyped individuals, 3,161, minus the number of extremes, 77. The number of controls for replication and combined is the number for discovery (3,084) plus the number of genotyped and phenotyped twins (∼865) minus the number of extreme twins (85) minus 35 twins not typed for this SNP.