Table 3.
rs7560738 (in TMEM163) associations with the eyes phenotype PC1 upper extreme in the combined sexes
| Discovery (both sexes) | aa | Aa | AA | P value | OR |
| Extremes | 9 | 30 | 103 | 4.39 × 10−7 | 10.15 |
| Controls | 20 | 577 | 2,422 | ||
| Replication (female only) | |||||
| Extremes | 3 | 23 | 57 | 2.50 × 10−3 | 5.12 |
| Controls | 29 | 729 | 3,040 | FDR = 0.026 | |
| Combined | |||||
| Extremes | 12 | 53 | 160 | 4.00 × 10−8 | 7.32 |
| Controls | 29 | 729 | 3,040 |
Minor allele (a) frequency 0.107. P values and OR are for the minor allele (aa) recessive homozygote; FDR by Benjamini and Hochberg procedure (37); All imaged individuals were used in the discovery analysis. The number of controls for discovery is the total number of genotyped individuals, 3,161, minus the number of extremes, 142. The number of controls for replication and combined is the number for discovery (3,019) plus the number of genotyped and phenotyped twins (∼865) minus the number of extreme twins (83). The discrepancy of 3 is a function of the way the twins are analyzed using random permutation.