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. 2018 Jan 8;115(4):E620–E629. doi: 10.1073/pnas.1715378115

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Fig. 2. — Global impairment of NCC development in Toupee^Tg/Tg embryos. (A and B) Quantification of Ki67⁺ proliferating (A) and _actCasp3⁺ apoptotic (B) NCCs (expressed in percentage of Sox10⁺ NCCs) in 30-μm transverse sections of E10.5 embryos at hindlimb level (Toupee^Tg/+ vs. Toupee^Tg/Tg). (C and D) Quantification of NCC migration speed (C) and movement persistence (D) in E10.5 embryos (WT;G4-RFP vs. Toupee^Tg/Tg;G4-RFP). (E) Quantification of the extent of colon colonization by enteric NCCs (expressed in percentage of colon length from cecum to anus) at E13.5 and E15.5 (Toupee^Tg/+;G4-RFP vs. Toupee^Tg/Tg;G4-RFP). (F) Volcano plot summarizing a RNA-seq–based analysis of differential gene expression levels in E10.5 NCCs (WT;G4-RFP vs. Toupee^Tg/Tg;G4-RFP). Only genes modulated at least 1.5-fold with a P value below 0.01 are displayed. **P ≤ 0.01 and ***P ≤ 0.001 (Student’s t test).