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. 2018 Jan 30;9:441. doi: 10.1038/s41467-017-02806-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Genome saturation by 119,452 ENU-induced mutations. The estimated probability of damage for each PP2 mutation class was incorporated into the calculation of genome saturation. Cumulative plot of genome saturation percentage vs. mutation number is shown for each specified cutoff number of G3 mice carrying truly damaging homozygous mutations. Mutations were non-synonymous coding and potential splicing changes