Table 1.
Mutations analyzed in this study
| Mutation classification | All mutations | Isolated mutations (>100 Mb from nearest neighbor) | Mutations from pedigrees with ≥3 G3 mice | Mutations in known essential genes |
|---|---|---|---|---|
| Probably benign (score ≤0.45) | 26,004 | 2,406 | 2,311 | 477 |
| Possibly damaging (score 0.45–0.95) | 14,412 | 1,314 | 1,270 | 281 |
| Probably damaging (score 0.95–1.0) | 32,669 | 3,077 | 2,982 | 690 |
| Probably null class I | 5,170 | 462 | 441 | 78 |
| Probably null class II | 2,618 | 273 | 268 | 60 |
| Total | 80,873 | 7,532 | 7,272 | 1,586 |
The columns represent progressive filtering steps from left to right