Figure 5.

Cathepsin G (CG) protein expression correlates with the concurrent expression of known leukemia-associated proteins. Pearson correlation coefficient analysis was performed to determine the association between the levels of CG and various selected proteins that are known to contribute to leukemogenesis and progression of ALL. These proteins were identified with a correlation coefficient threshold of 0.2. These proteins were assessed for both co-occurrence and inverse correlation with CG1; cell adhesion molecules TG2 and ITGB3, oncogene C-kit, proliferation-associated protein GATA1, and vascular protein VASP were among the proteins expressed at highest levels in association with CG, while tumor suppressor protein PTEN, apoptotic proteins SMAC and BCL2, and differentiation-promoting protein SSBP2 were expressed at low levels. All proteins were identified with a correlation coefficient threshold of 0.2.