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. 2018 Jan 26;11:571–585. doi: 10.2147/OTT.S152611

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© 2018 Shi et al. This work is published and licensed by Dove Medical Press Limited

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The enhanced CSC characters and metastatic abilities by miR-106b-5p overexpression could be abolished via the suppression of PTEN/PI3K/AKT pathway.

Notes: Western blotting showed that p-AKT level was downregulated in PLC/5 cells after LY294002 treatment (A), followed by the protein changes of CSC markers in PLC/5 cells (B). Transwell assays were performed to evaluate the effects of LY294002 on migration and invasion of PLC/5 cells with overexpression of miR-106b-5p or NC (C). Scale bars: 100 μm. Image showing the capability changes of sphere forming of PLC/5 cells after LY294002 treatment (D). Scale bars: 100 μm. *P<0.05, **P<0.01, ***P<0.001.

Abbreviations: CSC, cancer stem cell; PTEN, phosphatase and tensin homolog; NC, negative control.