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. 2018 Jan 26;13:569–583. doi: 10.2147/IJN.S153567

Figure 2.

Figure 2

Surface expression of co-stimulatory molecules by BMDCs upon exposure to PHYP, empty PLA nanospheres and free PHY, determined by flow cytometry (Dot plot representation).

Notes: (A) Gated CD11c-positive BMDC population analyzed. (B) Phenotypes of BMDCs after 48 h of stimulation. (C and D) Percentage of CD11c+CD86+ and CD11c+CD80+ cells upon exposure to PHYP, empty PLA nanospheres, and free PHY; consider LPS as positive control of maturation, and untreated BMDCs as negative controls. Data are expressed as mean ± SEM (n=3). ###p<0.001 vs PHY, *p<0.05 and ***p<0.001 vs the PLA group.

Abbreviations: BMDCs, bone marrow dendritic cells; CD, cluster of differentiation; LPS, lipopolysaccharide; PHY, pachyman; PHYP, PHY-encapsulated PLA; PLA, poly(D,L-lactic acid); SEM, standard error of the mean.