Table 3.

Hematologic adverse events of all CTCAE grades and grade 3–4

Hematologic adverse events	Number of subjects (N)	Number of studies (k)	I2	Fixed effect	95% CI	Random effect	95% CI
Adverse event (overall)
Anemia	1,058	12	98.4	0.653	0.624–0.681	0.546	0.299–0.782
Neutropenia	1,058	12	97.6	0.513	0.483–0.543	0.46	0.273–0.654
Thrombocytopenia	1,037	11	96.8	0.298	0.271–0.326	0.255	0.125–0.412
Febrile neutropenia	815	8	70.4	0.06	0.045–0.078	0.066	0.033–0.110
Adverse event (grade 3–4)
Neutropenia	1,521	18	94.3	0.264	0.242–0.286	0.246	0.165–0.338
Anemia	1,222	15	86.5	0.115	0.098–0.133	0.102	0.059–0.154
Febrile neutropenia	995	12	38.6	0.055	0.042–0.070	0.054	0.035–0.076
Thrombocytopenia	1,073	11	69.6	0.032	0.022–0.043	0.03	0.013–0.054

Abbreviation: CTCAE, Common Terminology Criteria for Adverse Events.