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. 2018 Jan 25;13:525–536. doi: 10.2147/IJN.S149532

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© 2018 Jeong et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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In vivo antitumor activity of psi-hBCL2/AEMA-g-WSC complexes. (A) Distribution of tumor volumes after injection of psi-hBCL2/WSC at a 1:64 w/w ratio or psi-hBCL2/AEMA-g-WSC at a 1:8 w/w ratio. (B) H&E histological analysis of harvested tumors (×200): (a) control, (b) psi-hBCL2/WSC, (c) psi-hBCL2/AEMA-g-WSC. (C) Immunohistochemical analysis of harvested tumors with anti-BCL2 and anti-caspase-3 monoclonal antibodies: (a) control, (b) psi-hBCL2/WSC, (c) psi-hBCL2/AEMA-g-WSC.

Abbreviation: AEMA-g-WSC, 2-aminoethyl methacrylate-grafted water-soluble chitosan.